Presentation at the Lancet Summit on GeNeuro’s new anti-HERV-K antibody for amyotrophic lateral sclerosis


GeNeuro (Paris: GNRO) (Euronext Paris: CH0308403085 – GNRO), a biopharmaceutical company developing new treatments for neurological and autoimmune diseases, today announced that its Scientific Director, Dr Hervé Perron, unveiled today ‘ hui at “The Lancet Summit: Presymptomatic Prevention and Treatment of Neurodegenerative Diseases” additional findings from the Amyotrophic Lateral Sclerosis (ALS) Preclinical Research Program developed in partnership with the National Institute of Neurological Disorders and Stroke (NINDS), which is part from the United States National Institutes of Health (NIH).

“This joint NINDS / GeNeuro study showed the specific and effective inhibition of the neurotoxic effects of HERV-K ENV from the extracellular medium in vitro and in vivo, using the anti HERV-K K01 monoclonal antibody from GeNeuro,” noted Dr Hervé Perron, Scientific Director of GeNeuro.

A new pathogenic mechanism has been unveiled and characterized, and these results open up new perspectives for a therapeutic intervention against sporadic ALS ”, said Dr Avindra Nath, clinical director of the National Institute of Neurological Disorders and Stroke, who heads the joint NINDS / GeNeuro ALS research program.

These results, following those presented by Dr. Avindra Nath at the American Neurological Association (ANA) annual meeting on October 17, 2021, show in vitro and in vivo the neurotoxic effects specifically mediated by HERV-K ENV, a retroviral envelope protein encoded by a pathogenic member of the HERV-K family of endogenous human retroviruses (HERV-K ENV protein). More importantly, they confirm the neutralizing effects of the novel anti-HERV-K monoclonal antibody specific for GeNeuro.

As previously mentioned, GeNeuro’s preclinical development program has enabled its anti-HERV-K ENV antibody to now be humanized and ready to go into GMP manufacturing. The program could start clinical trials as early as 2022.

These results confirm the potentially key role of HERV-K ENV in ALS and the potential of the new GeNeuro antibody in this indication.,” noted Jesús Martin-Garcia, CEO of GeNeuro. “We will now seek partnerships to bring this product to patients as quickly as possible.

The presentation is available on GeNeuro’s Youtube channel.

About ALS

Amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig’s disease or clinically motor neuron disease, is a fatal and rapidly progressive neurodegenerative disease characterized by loss of motor neurons leading to progressive muscle paralysis. The incidence of ALS is approximately 5 per 100,000 people in the United States, 1 in 3 per 100,000 people worldwide, and is constant in various populations.

About GeNeuro

GeNeuro’s mission is to develop safe and effective treatments against neurological disorders and autoimmune diseases, such as multiple sclerosis, by neutralizing the causal factors encoded by HERVs, which make up 8% of human DNA. .

GeNeuro is based in Geneva, Switzerland, and has R&D facilities in Lyon, France. It owns the rights to 17 patent families protecting its technology.

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